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Not necessarily but you may find some. The biggest factor I have found with different profiles is the difference in seating depth which directly effects case volume and powder charge. A starting load may be same but the Max will be different. This is not to say the same charge won't be safe with different profiles just that it can result in different load levels.
after a while you get pretty good at comparing how much case capacity you have to work with.
the good thing is you have jacketed loads to compare to and generally a naked lead boolit will have a lower pressure so you get some wiggle room to help.
[about the only time you get into trouble 'reducing just a titch more' is with stuff like H-110.]
and the worst that can happen is you have to knock a stuck boolit out of a barrel.
I have never really noticed any difference, and the start loads for one are good for all the others. I you look at a lyman manual, you'll see no more than about 0.3gn difference for the same weight lead bullet.
I see as much difference from a long-nose SWC and a button-nose SWC as I do a RN from a FN from any of the SWC.